Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature Pmc

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  • A left anterior indirect view of the right coronary system, demonstrating a complete occlusion of the mid right coronary artery with thrombus.
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Discussion And Review Of The Literature

We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac danger components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the right coronary artery. Physicians and patients ought to be aware of the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity.

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However, testosterone in physiologic doses could even be useful in patients with angina , have greater ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in males with established coronary artery disease . Therefore, an interplay of endogenous factors of the patient’s threat profile as well as the testosterone dosing may be problems with whether or not adverse events happen. Erythrocytosis has been reported as a possible impact of testosterone, which could be useful in sufferers with anemia.

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Patients additionally could additionally be taking concomitant stimulants, such as ephedra, which might confound data and the potential for opposed events. It is probably going that the frequency of cardiac events is underreported in the medical literature. Moreover, testosterone has been used in the therapy of lowered muscle mass and bone density in addition to anemia. The role testosterone might play within the improvement of cardiovascular disease has more and more become the topic of present interest . Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 pure and synthetic derivatives of testosterone, could cause a wide spectrum of clinical sequalae. Supplemental or physiologic doses of testosterone have seen expanded use in medical follow just lately. Other common potential adverse effects embrace infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .

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